Olmesartan, Amlodipine and Hydrochlorothiazide are combined in this medicine.
This medicine helps to keep your blood pressure under control.
Take Olmesartan + Amlodipine + Hydrochlorothiazide exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
Swallow the tablet whole with a glass of water. Do not chew or crush the tablet.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your condition and your response to the medication.
Olmesartan + Amlodipine + Hydrochlorothiazide must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Do not take Olmesartan + Amlodipine + Hydrochlorothiazide if you ever had an allergic reaction (e.g. rashes, breathlessness, swollen eyes) to this medicine or sulfonamide-derived medicines (medicines used to treat certain infections).
Alert your doctor if you have the following conditions:
- inability to pass urine
- very low blood pressure
- heart failure (weakness and inability of the heart to pump blood) after a heart attack
- cardiogenic shock (a serious sudden condition when the heart cannot supply enough oxygen-rich blood to the brain and vital organs of the body)
- blocked bile duct (a tube-like channel which carries bile from the liver to the upper portion of the small intestine)
- high levels of calcium or uric acid in your blood
- low levels of potassium or sodium in your blood
- severe kidney disease
- severe liver disease
as Olmesartan + Amlodipine + Hydrochlorothiazide may not be suitable for you.
Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Olmesartan + Amlodipine + Hydrochlorothiazide, alert your doctor immediately. This medicine may cause harm to your unborn child.
Do not breastfeed while you are being treated with this medicine.
Do not take Olmesartan + Amlodipine + Hydrochlorothiazide with aliskiren (medicine for high blood pressure) if you have diabetes or kidney disease.
Inform your doctor if you have the following conditions:
- low volume of circulating fluids in the blood
- narrowing of the heart valves
- abnormally thick heart muscle that results in blockage of blood flow
- prediabetes (a condition in which the blood sugar levels are higher than normal but not high enough to be diagnosed as diabetes) or diabetes
- primary aldosteronism (a condition in which the adrenal glands produce excessive amounts of a hormone known as aldosterone)
- thyroid disease
- systemic lupus erythematosus (autoimmune disease that causes inflammation of certain organs in the body)
- mild to moderate kidney disease
- mild to moderate liver disease
Be sure to check with your doctor or pharmacist before giving Olmesartan + Amlodipine + Hydrochlorothiazide to the elderly. Elderly people may be more sensitive to the side effects.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests (e.g. kidney function, electrolyte levels) may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure regularly during treatment.
What lifestyle changes can I make to improve my blood pressure?
Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.
If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.
Olmesartan + Amlodipine + Hydrochlorothiazide may cause dizziness, headache, nausea or tiredness. If affected, do not drive or take part in any activity in which you need to be alert.
This medicine may also make your skin more sensitive to sunlight. Apply sunscreen when going outdoors and avoid prolonged exposure to sunlight and UV lamps.
Other side effects include any of the following: constipation, diarrhoea, muscle spasms, and swollen joints.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- increased pressure in the eye, changes in eyesight, eye pain
- signs and symptoms of allergic reaction e.g. rashes, breathlessness, swelling of the face, eyes or mouth
- severe itching of the skin with lumps, changes in colour or size of a mole
- severe diarrhoea with significant weight loss
- muscle weakness, cramping or numbness; fast or irregular heartbeat
- pain or difficulty in passing urine, change in how much urine is passed, blood in the urine
- signs and symptoms of heart attack e.g. chest pain, tightness or pressure, pain that may spread to the arms, jaw, neck, shoulder or back, shortness of breath, lightheadedness
- swelling of the ankles, feet or hands
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Olmesartan + Amlodipine + Hydrochlorothiazide with aliskiren (medicine for high blood pressure) if you have diabetes or kidney disease.
Inform your doctor and pharmacist if you are taking any of these medicines:
- heparin (blood-thinning medicine)
- rifampicin (medicine to treat TB [an infection known as tuberculosis])
- medicines for heart disease e.g. diltiazem, verapamil
- medicines to treat depression
- medicines for mood disorders e.g. lithium, chlorpromazine, haloperidol
- medicines for epilepsy (fits or seizures)
- other medicines for high blood pressure
- water pills or medicines for water retention
- certain antibiotics e.g. benzylpenicillin, clarithromycin
- medicines for HIV infection e.g. ritonavir, indinavir
- certain medicines to treat fungal infection e.g. ketoconazole, itraconazole, amphotericin B
- NSAIDs (medicines for pain and inflammation) e.g. ibuprofen, celecoxib
- medicines for diabetes e.g. insulin
- cholesterol-lowering medicines e.g. colesevelam, simvastatin
- medicines for cancer e.g. cyclophosphamide, methotrexate
- medicines used in organ transplants or certain immune disorders e.g. ciclosporin, sirolimus, tacrolimus
- potassium supplements
- strong painkillers
- St. John's wort (herbal medicine)
This list does not include all medicines that may interact with Olmesartan + Amlodipine + Hydrochlorothiazide.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).
Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Discuss with your doctor or dietitian about ways to cut down on your salt intake.
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
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